Cambridge took a huge stride towards securing a play-off place with a comfortable win at 10-man Salisbury.
Jack Jeffrey scored the opener and then laid on the second for Mark Beesley after Mike Fowler had been sent off for a dangerous tackle on Stephen Reed.
Aaron Cook missed Salisbury's best chance of the match when he headed Liam Feeney's inswinging corner wide of the post from six yards.
A win in either of Cambridge's last two matches will earn them a play-off spot.
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