National League Two side Oldham face a trip to Wakefield Wildcats in the quarter-finals of the Challenge Cup.
Holders St Helens have been drawn away against Hull KR and Bradford Bulls host Hull FC in the next round to be played on the weekend of 31 May and 1 June.
Wigan face a trip to Super League rivals Leeds after trouncing Division One side Whitehaven 106-8 in the remaining fifth-round tie on Monday.
Leeds booked their berth with victory over Harlequins on Sunday.
St Helens coach Daniel Anderson will be looking to avenge Saints' defeat at Hull KR in the opening round of this season's Super League.
"That's a long time ago now - we're a different team and so are they," he said.
"It's an intriguing tie. I think all the ties are pretty intriguing to tell the truth. It looks like it's going to be a very good weekend."
Quarter-final draw:
Wakefield v Oldham
Leeds v Wigan
Hull KR v St Helens
Bradford v Hull
Ties to be played on the weekend of 31 May-1 June.
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